Strategies to direct the enrichment, expansion, and recruitment of regulatory cells for the treatment of disease
Identifieur interne : 001172 ( Main/Exploration ); précédent : 001171; suivant : 001173Strategies to direct the enrichment, expansion, and recruitment of regulatory cells for the treatment of disease
Auteurs : Andrew J. Glowacki [États-Unis] ; Riccardo Gottardi [États-Unis, Italie] ; Sayuri Yoshizawa [États-Unis] ; Franco Cavalla [Brésil, Chili] ; Gustavo P. Garlet [Brésil] ; Charles Sfeir [États-Unis] ; Steven R. Little [États-Unis]Source :
- Annals of biomedical engineering [ 0090-6964 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
Abstract
Disease and injury perturb the balance of processes associated with inflammation and tissue remodeling, resulting in positive feedback loops, exacerbation of disease and compromised tissue repair. Conversely, under homeostatic healthy conditions, these processes are tightly regulated through the expansion and/or recruitment of specific cell populations, promoting a balanced steady-state. Better understanding of these regulatory processes and recent advances in biomaterials and biotechnology have prompted strategies to utilize cells for the treatment and prevention of disease through regulation of inflammation and promotion of tissue repair. Herein, we describe how cells that regulate these processes can be increased in prevalence at a site of disease or injury. We review several relevant cell therapy approaches as well as new strategies for directing endogenous regulatory cells capable of promoting environmental homeostasis and even the establishment of a pro-regenerative micro-environment. Collectively, these examples may provide a blueprint for next-generation “medicine” that spurs the body’s own cells to action and replaces conventional drugs.
Url:
DOI: 10.1007/s10439-014-1125-2
PubMed: 25245220
PubMed Central: 4370807
Affiliations:
- Brésil, Chili, Italie, États-Unis
- Pennsylvanie, État de São Paulo
- Pittsburgh, São Paulo
- Université de Pittsburgh, Université de São Paulo
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000E07
- to stream Pmc, to step Curation: 000D82
- to stream Pmc, to step Checkpoint: 000518
- to stream PubMed, to step Corpus: 000461
- to stream PubMed, to step Curation: 000461
- to stream PubMed, to step Checkpoint: 000461
- to stream Ncbi, to step Merge: 003685
- to stream Ncbi, to step Curation: 003685
- to stream Ncbi, to step Checkpoint: 003685
- to stream Main, to step Merge: 001196
- to stream Main, to step Curation: 001172
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Strategies to direct the enrichment, expansion, and recruitment of regulatory cells for the treatment of disease</title><author><name sortKey="Glowacki, Andrew J" sort="Glowacki, Andrew J" uniqKey="Glowacki A" first="Andrew J." last="Glowacki">Andrew J. Glowacki</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Gottardi, Riccardo" sort="Gottardi, Riccardo" uniqKey="Gottardi R" first="Riccardo" last="Gottardi">Riccardo Gottardi</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A4">Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Ri.MED Foundation, Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Ri.MED Foundation, Palermo</wicri:regionArea><wicri:noRegion>Palermo</wicri:noRegion></affiliation></author><author><name sortKey="Yoshizawa, Sayuri" sort="Yoshizawa, Sayuri" uniqKey="Yoshizawa S" first="Sayuri" last="Yoshizawa">Sayuri Yoshizawa</name><affiliation wicri:level="4"><nlm:aff id="A2">Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A5">Department of Oral Biology, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral Biology, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Cavalla, Franco" sort="Cavalla, Franco" uniqKey="Cavalla F" first="Franco" last="Cavalla">Franco Cavalla</name><affiliation wicri:level="4"><nlm:aff id="A10">Department of Biological Sciences, School of Dentistry of Bauru, University of Sao Paulo, Bauru, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Biological Sciences, School of Dentistry of Bauru, University of Sao Paulo, Bauru</wicri:regionArea><orgName type="university">Université de São Paulo</orgName><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Department of Conservative Dentistry, Faculty of Dentistry University of Chile, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Department of Conservative Dentistry, Faculty of Dentistry University of Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Garlet, Gustavo P" sort="Garlet, Gustavo P" uniqKey="Garlet G" first="Gustavo P." last="Garlet">Gustavo P. Garlet</name><affiliation wicri:level="4"><nlm:aff id="A10">Department of Biological Sciences, School of Dentistry of Bauru, University of Sao Paulo, Bauru, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Biological Sciences, School of Dentistry of Bauru, University of Sao Paulo, Bauru</wicri:regionArea><orgName type="university">Université de São Paulo</orgName><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Sfeir, Charles" sort="Sfeir, Charles" uniqKey="Sfeir C" first="Charles" last="Sfeir">Charles Sfeir</name><affiliation wicri:level="4"><nlm:aff id="A2">Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A5">Department of Oral Biology, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral Biology, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A6">Department of Periodontics/Preventative Dentistry, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Periodontics/Preventative Dentistry, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Little, Steven R" sort="Little, Steven R" uniqKey="Little S" first="Steven R." last="Little">Steven R. Little</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A7">Department of Immunology, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Immunology, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A8">Department of Bioengineering, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25245220</idno><idno type="pmc">4370807</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370807</idno><idno type="RBID">PMC:4370807</idno><idno type="doi">10.1007/s10439-014-1125-2</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000E07</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E07</idno><idno type="wicri:Area/Pmc/Curation">000D82</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D82</idno><idno type="wicri:Area/Pmc/Checkpoint">000518</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000518</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000461</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000461</idno><idno type="wicri:Area/PubMed/Curation">000461</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000461</idno><idno type="wicri:Area/PubMed/Checkpoint">000461</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000461</idno><idno type="wicri:Area/Ncbi/Merge">003685</idno><idno type="wicri:Area/Ncbi/Curation">003685</idno><idno type="wicri:Area/Ncbi/Checkpoint">003685</idno><idno type="wicri:doubleKey">0090-6964:2014:Glowacki A:strategies:to:direct</idno><idno type="wicri:Area/Main/Merge">001196</idno><idno type="wicri:Area/Main/Curation">001172</idno><idno type="wicri:Area/Main/Exploration">001172</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Strategies to direct the enrichment, expansion, and recruitment of regulatory cells for the treatment of disease</title><author><name sortKey="Glowacki, Andrew J" sort="Glowacki, Andrew J" uniqKey="Glowacki A" first="Andrew J." last="Glowacki">Andrew J. Glowacki</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Gottardi, Riccardo" sort="Gottardi, Riccardo" uniqKey="Gottardi R" first="Riccardo" last="Gottardi">Riccardo Gottardi</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A4">Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Ri.MED Foundation, Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Ri.MED Foundation, Palermo</wicri:regionArea><wicri:noRegion>Palermo</wicri:noRegion></affiliation></author><author><name sortKey="Yoshizawa, Sayuri" sort="Yoshizawa, Sayuri" uniqKey="Yoshizawa S" first="Sayuri" last="Yoshizawa">Sayuri Yoshizawa</name><affiliation wicri:level="4"><nlm:aff id="A2">Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A5">Department of Oral Biology, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral Biology, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Cavalla, Franco" sort="Cavalla, Franco" uniqKey="Cavalla F" first="Franco" last="Cavalla">Franco Cavalla</name><affiliation wicri:level="4"><nlm:aff id="A10">Department of Biological Sciences, School of Dentistry of Bauru, University of Sao Paulo, Bauru, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Biological Sciences, School of Dentistry of Bauru, University of Sao Paulo, Bauru</wicri:regionArea><orgName type="university">Université de São Paulo</orgName><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Department of Conservative Dentistry, Faculty of Dentistry University of Chile, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Department of Conservative Dentistry, Faculty of Dentistry University of Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Garlet, Gustavo P" sort="Garlet, Gustavo P" uniqKey="Garlet G" first="Gustavo P." last="Garlet">Gustavo P. Garlet</name><affiliation wicri:level="4"><nlm:aff id="A10">Department of Biological Sciences, School of Dentistry of Bauru, University of Sao Paulo, Bauru, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Biological Sciences, School of Dentistry of Bauru, University of Sao Paulo, Bauru</wicri:regionArea><orgName type="university">Université de São Paulo</orgName><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Sfeir, Charles" sort="Sfeir, Charles" uniqKey="Sfeir C" first="Charles" last="Sfeir">Charles Sfeir</name><affiliation wicri:level="4"><nlm:aff id="A2">Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A5">Department of Oral Biology, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral Biology, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A6">Department of Periodontics/Preventative Dentistry, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Periodontics/Preventative Dentistry, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Little, Steven R" sort="Little, Steven R" uniqKey="Little S" first="Steven R." last="Little">Steven R. Little</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A7">Department of Immunology, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Immunology, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A8">Department of Bioengineering, University of Pittsburgh, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author></analytic><series><title level="j">Annals of biomedical engineering</title><idno type="ISSN">0090-6964</idno><idno type="eISSN">1573-9686</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell- and Tissue-Based Therapy</term><term>Homeostasis</term><term>Humans</term><term>Mesenchymal Stromal Cells (physiology)</term><term>Regeneration</term><term>T-Lymphocytes, Regulatory (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules stromales mésenchymateuses (physiologie)</term><term>Homéostasie</term><term>Humains</term><term>Lymphocytes T régulateurs (physiologie)</term><term>Régénération</term><term>Thérapie cellulaire et tissulaire</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cellules stromales mésenchymateuses</term><term>Lymphocytes T régulateurs</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Mesenchymal Stromal Cells</term><term>T-Lymphocytes, Regulatory</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell- and Tissue-Based Therapy</term><term>Homeostasis</term><term>Humans</term><term>Regeneration</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Homéostasie</term><term>Humains</term><term>Régénération</term><term>Thérapie cellulaire et tissulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Disease and injury perturb the balance of processes associated with inflammation and tissue remodeling, resulting in positive feedback loops, exacerbation of disease and compromised tissue repair. Conversely, under homeostatic healthy conditions, these processes are tightly regulated through the expansion and/or recruitment of specific cell populations, promoting a balanced steady-state. Better understanding of these regulatory processes and recent advances in biomaterials and biotechnology have prompted strategies to utilize cells for the treatment and prevention of disease through regulation of inflammation and promotion of tissue repair. Herein, we describe how cells that regulate these processes can be increased in prevalence at a site of disease or injury. We review several relevant cell therapy approaches as well as new strategies for directing endogenous regulatory cells capable of promoting environmental homeostasis and even the establishment of a pro-regenerative micro-environment. Collectively, these examples may provide a blueprint for next-generation “medicine” that spurs the body’s own cells to action and replaces conventional drugs.</p></div></front></TEI><affiliations><list><country><li>Brésil</li><li>Chili</li><li>Italie</li><li>États-Unis</li></country><region><li>Pennsylvanie</li><li>État de São Paulo</li></region><settlement><li>Pittsburgh</li><li>São Paulo</li></settlement><orgName><li>Université de Pittsburgh</li><li>Université de São Paulo</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Glowacki, Andrew J" sort="Glowacki, Andrew J" uniqKey="Glowacki A" first="Andrew J." last="Glowacki">Andrew J. Glowacki</name></region><name sortKey="Glowacki, Andrew J" sort="Glowacki, Andrew J" uniqKey="Glowacki A" first="Andrew J." last="Glowacki">Andrew J. Glowacki</name><name sortKey="Glowacki, Andrew J" sort="Glowacki, Andrew J" uniqKey="Glowacki A" first="Andrew J." last="Glowacki">Andrew J. Glowacki</name><name sortKey="Gottardi, Riccardo" sort="Gottardi, Riccardo" uniqKey="Gottardi R" first="Riccardo" last="Gottardi">Riccardo Gottardi</name><name sortKey="Gottardi, Riccardo" sort="Gottardi, Riccardo" uniqKey="Gottardi R" first="Riccardo" last="Gottardi">Riccardo Gottardi</name><name sortKey="Gottardi, Riccardo" sort="Gottardi, Riccardo" uniqKey="Gottardi R" first="Riccardo" last="Gottardi">Riccardo Gottardi</name><name sortKey="Little, Steven R" sort="Little, Steven R" uniqKey="Little S" first="Steven R." last="Little">Steven R. Little</name><name sortKey="Little, Steven R" sort="Little, Steven R" uniqKey="Little S" first="Steven R." last="Little">Steven R. Little</name><name sortKey="Little, Steven R" sort="Little, Steven R" uniqKey="Little S" first="Steven R." last="Little">Steven R. Little</name><name sortKey="Little, Steven R" sort="Little, Steven R" uniqKey="Little S" first="Steven R." last="Little">Steven R. Little</name><name sortKey="Little, Steven R" sort="Little, Steven R" uniqKey="Little S" first="Steven R." last="Little">Steven R. Little</name><name sortKey="Sfeir, Charles" sort="Sfeir, Charles" uniqKey="Sfeir C" first="Charles" last="Sfeir">Charles Sfeir</name><name sortKey="Sfeir, Charles" sort="Sfeir, Charles" uniqKey="Sfeir C" first="Charles" last="Sfeir">Charles Sfeir</name><name sortKey="Sfeir, Charles" sort="Sfeir, Charles" uniqKey="Sfeir C" first="Charles" last="Sfeir">Charles Sfeir</name><name sortKey="Sfeir, Charles" sort="Sfeir, Charles" uniqKey="Sfeir C" first="Charles" last="Sfeir">Charles Sfeir</name><name sortKey="Yoshizawa, Sayuri" sort="Yoshizawa, Sayuri" uniqKey="Yoshizawa S" first="Sayuri" last="Yoshizawa">Sayuri Yoshizawa</name><name sortKey="Yoshizawa, Sayuri" sort="Yoshizawa, Sayuri" uniqKey="Yoshizawa S" first="Sayuri" last="Yoshizawa">Sayuri Yoshizawa</name><name sortKey="Yoshizawa, Sayuri" sort="Yoshizawa, Sayuri" uniqKey="Yoshizawa S" first="Sayuri" last="Yoshizawa">Sayuri Yoshizawa</name></country><country name="Italie"><noRegion><name sortKey="Gottardi, Riccardo" sort="Gottardi, Riccardo" uniqKey="Gottardi R" first="Riccardo" last="Gottardi">Riccardo Gottardi</name></noRegion></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Cavalla, Franco" sort="Cavalla, Franco" uniqKey="Cavalla F" first="Franco" last="Cavalla">Franco Cavalla</name></region><name sortKey="Garlet, Gustavo P" sort="Garlet, Gustavo P" uniqKey="Garlet G" first="Gustavo P." last="Garlet">Gustavo P. Garlet</name></country><country name="Chili"><noRegion><name sortKey="Cavalla, Franco" sort="Cavalla, Franco" uniqKey="Cavalla F" first="Franco" last="Cavalla">Franco Cavalla</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001172 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001172 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Amérique
|area= PittsburghV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4370807
|texte= Strategies to direct the enrichment, expansion, and recruitment of regulatory cells for the treatment of disease
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25245220" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PittsburghV1
| This area was generated with Dilib version V0.6.38. |  |